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The International Stroke Genetics Consortium (ISGC) was created in April 2007 by a group of 16 investigators from Europe and North America interested in stroke genetics research. Since then, the ISGC has held one international workshop every six months, hosted by ISGC members from around the world, and has become an international, multidisciplinary network of more than 200 stroke genetics investigators, representing over 38 countries in 6 continents.
 

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Workshops

Dear ISGC members,
In preparation for our ISGC workshop in Munich taking place from April 24-26, 2024, we would like to share this teaser...

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On behalf of the hosts of the event , Natalia Rost and Patricia Musolino from the Massachusetts General Hospital, thank you for a great workshop...

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Dear ISGC colleagues,

Next January 30th (Europe and US) and 31th (Asia) we will have our first Virtual Workshop of the year! The Virtual...

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Working Groups

Among the goals of this committee are to increase efficiency of analyses and create an expert community to aid in solving problems faced by less experienced ISGC members.

Our mission is to decipher genetic determinants, both single gene and complex inheritance of early-onset stroke and cerebrovascular disease and search for the pathways through which they alter stroke susceptibility. We expect that this effort will lead to better treatments for Mendelian forms of stroke and will identify novel biological mechanisms that are also relevant to older-onset stroke.

This group undertakes harmonization of image characterization/measurement approaches across ISGC centers and contributes images to the ISGC-NINDS stroke imaging repository at MGH.

Formed in the fall of 2012, this group is responsible for harmonizing stroke outcome measures across member sites.

This working group is devoted to expanding ISGC participation to underrepresented regions and populations.

The goal of this group is uniting researchers whose goal is to use genetic and genomic tools to improve understanding of the pathophysiologic basis of cerebrovascular disease.

Projects

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Members of the day

Professor Arne Lindgren, MD, PhD

Arne Lindgren is Professor of Neurology at Lund University, and consultant Neurologist at Skane...
Dr Pankaj Sharma, MD

Dr Sharma's main interest is in identifying genes for stroke (including in ethnic minority...
Professor Philip Oluleke Ibinaiye

IBINAIYE, Philip Oluleke is a Professor and Consultant Neurovascular Radiologist at Ahmadu Bello...
Dr Bradford B Worrall, MD, MSc

Bradford B Worrall, MD, MSc is a Professor and Vice-Chair for Clinical Research of Neurology and...
Dr Jordi Jiménez-Conde, MD, PhD

Dr Jordi Jiménez-Conde is a vascular neurologist of the Department of Neurology, head of...

New Papers

Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors

Mark K. Bakker, Rick A. A. van der Spek, Wouter van Rheenen, Sandrine Morel, Romain Bourcier, Isabel C. Hostettler, Varinder S. Alg, Kristel R. van Eijk, Masaru Koido, Masato Akiyama, Chikashi Terao, Koichi Matsuda, Robin G. Walters, Kuang Lin, Liming Li, Iona Y. Millwood, Zhengming Chen, Guy A. Rouleau, Sirui Zhou, Kristiina Rannikmäe, Cathie L. M. Sudlow, Henry Houlden, Leonard H. van den Berg, Christian Dina, Olivier Naggara, Jean-Christophe Gentric, Eimad Shotar, François Eugène, Hubert Desal, Bendik S. Winsvold, Sigrid Børte, Marianne Bakke Johnsen, Ben M. Brumpton, Marie Søfteland Sandvei, Cristen J. Willer, Kristian Hveem, John-Anker Zwart, W. M. Monique Verschuren, Christoph M. Friedrich, Sven Hirsch, Sabine Schilling, Jérôme Dauvillier, Olivier Martin, HUNT All-In Stroke, China Kadoorie Biobank Collaborative Group, BioBank Japan Project Consortium, The ICAN Study Group, CADISP Group, Genetics and Observational Subarachnoid Haemorrhage (GOSH) Study investigators, International Stroke Genetics Consortium (ISGC), Gregory T. Jones, Matthew J. Bown, Nerissa U. Ko, Helen Kim, Jonathan R. I. Coleman, Gerome Breen, Jonathan G. Zaroff, Catharina J. M. Klijn, Rainer Malik, Martin Dichgans, Muralidharan Sargurupremraj, Turgut Tatlisumak, Philippe Amouyel, Stéphanie Debette, Gabriel J. E. Rinkel, Bradford B. Worrall, Joanna Pera, Agnieszka Slowik, Emília I. Gaál-Paavola, Mika Niemelä, Juha E. Jääskeläinen, Mikael von Und Zu Fraunberg, Antti Lindgren, Joseph P. Broderick, David J. Werring, Daniel Woo, Richard Redon, Philippe Bijlenga, Yoichiro Kamatani, Jan H. Veldink & Ynte M. Ruigrok
Nature Genetics 52, 1303–1313 (2020). https://doi.org/10.1038/s41588-020-00725-7 [ PUBMED ]

Genome-wide association meta-analysis of functional outcome after ischemic stroke.

Söderholm M, Pedersen A, Lorentzen E, Stanne TM, Bevan S, Olsson M, Cole JW, Fernandez-Cadenas I, Hankey GJ, Jimenez-Conde J, Jood K, Lee JM, Lemmens R, Levi C, Mitchell BD, Norrving B, Rannikmäe K, Rost NS, Rosand J, Rothwell PM, Scott R, Strbian D, Sturm JW, Sudlow C, Traylor M, Thijs V, Tatlisumak T, Woo D, Worrall BB, Maguire JM, Lindgren A, Jern C; International Stroke Genetics Consortium, the NINDS-SiGN Consortium, and the Genetics of Ischaemic Stroke Functional Outcome (GISCOME) Network.
Neurology. 2019 Mar 19;92(12):e1271-e1283. [ PUBMED ]

Genetic Imbalance Is Associated With Functional Outcome After Ischemic Stroke.

Pfeiffer D, Chen B, Schlicht K, Ginsbach P, Abboud S, Bersano A, Bevan S, Brandt T, Caso V, Debette S, Erhart P, Freitag-Wolf S, Giacalone G, Grau AJ, Hayani E, Jern C, Jiménez-Conde J, Kloss M, Krawczak M, Lee JM, Lemmens R, Leys D, Lichy C, Maguire JM, Martin JJ, Metso AJ, Metso TM, Mitchell BD, Pezzini A, Rosand J, Rost NS, Stenman M, Tatlisumak T, Thijs V, Touzé E, Traenka C, Werner I, Woo D, Del Zotto E, Engelter ST, Kittner SJ, Cole JW, Grond-Ginsbach C, Lyrer PA, Lindgren; CADISP; GISCOME; SiGN studies; and ISGC.
Stroke. 2019 Feb;50(2):298-304. [ PUBMED ]

Genome-wide meta-analysis identifies 3 novel loci associated with stroke.

Malik R, Rannikmäe K, Traylor M, Georgakis MK, Sargurupremraj M, Markus HS, Hopewell JC, Debette S, Sudlow CLM, Dichgans M; MEGASTROKE consortium and the International Stroke Genetics Consortium.
Ann Neurol. 2018 Nov 1. doi: 10.1002/ana.25369. [ PUBMED ]

Genetic risk, incident stroke, and the benefits of adhering to a healthy lifestyle: cohort study of 306 473 UK Biobank participants.

Rutten-Jacobs LC, Larsson SC, Malik R, Rannikmäe K; MEGASTROKE consortium; International Stroke Genetics Consortium, Sudlow CL, Dichgans M, Markus HS, Traylor M.
BMJ. 2018 Oct 24;363:k4168. doi: 10.1136/bmj.k4168. [ PUBMED ]